Highly Stable Indomethacin Glasses Resist Uptake of Water Vapor

Authors:
  • KKKenneth L. Kearns
    Kenneth L. Kearns
  • MEM. D. Ediger
    M. D. Ediger
  • MSMark J. Sacchetti
    Mark J. Sacchetti
  • GZGeorge D. Zografi
    George D. Zografi
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Abstract
Mass uptake of water vapor was measured as a function of relative humidity for indomethacin glasses prepared using physical vapor deposition at different substrate temperatures. Highly stable glasses were produced on substrates at 265 K (0.84Tg) by depositing at 0.2 nm/s while samples similar to melt-cooled glasses were produced at 315 K and 5 nm/s. Samples deposited at 315 K absorb approximately the same amount of water as glasses prepared by supercooling the melt while stable glasses absorb a factor of 5 less water. Unexpectedly, the diffusion of water in the stable glass samples is 5−10 times faster than in the glass prepared by cooling the liquid.

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