Is obesity the missing link? Ultra-processed foods and metabolic and reproductive outcomes: a narrative review
Open Access
- 29 April 2026
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Nutrition
- Vol. 13, 1800945
Abstract
Ultra-processed food (UPF) has been extensively linked to obesity, diabetes, hypertension, metabolic disease, and cancer. It also contributes to the development of inflammation, oxidative stress, and other disease pathways, with obesity being a major concern. In this review, we offer insights into the role of UPF consumption on nutritional behavior, diet quality, and health. We also raise the questions of whether UPF promotes obesity that subsequently mediates the development of infertility, metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and hypertension, and whether UPF independently drives these conditions through obesity-independent pathways. Understanding the impact of UPF on diet quality and health can guide strategies to reduce its consumption and address related public health and sustainability challenges.Keywords
This publication has 142 references indexed in Scilit:
- Comparison of food processing classification frameworks in the NHANES 2017–2018The American Journal of Clinical Nutrition, 2026
- The impact of ultra-processed foods on cardiovascular diseases and cancer: Epidemiological and mechanistic insightsAspects of Molecular Medicine, 2025
- Global Prevalence of Nonalcoholic Fatty Liver Disease: An Updated Review Meta-Analysis comprising a Population of 78 million from 38 CountriesArchives of Medical Research, 2024
- Ultraprocessed Foods and Obesity Risk: A Critical Review of Reported MechanismsAdvances in Nutrition, 2023
- The challenges of obesity for fertility: A FIGO literature reviewInternational Journal of Gynecology & Obstetrics, 2023
- Characterization of the Degree of Food Processing in Relation With Its Health Potential and Effects2018
- Consumption of ultra-processed foods predicts diet quality in CanadaAppetite, 2017
- Global Changes in Food Supply and the Obesity EpidemicCurrent Obesity Reports, 2016
- Food Classification Systems Based on Food Processing: Significance and Implications for Policies and Actions: A Systematic Literature Review and AssessmentCurrent Obesity Reports, 2014
- Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitusJournal of Cellular Biochemistry, 2013