ATR activity controls stem cell quiescence via the cyclin F–SCF complex
Open Access
- 27 April 2022
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 119 (18)
Abstract
Significance: The replication stress response protein, ATR, is active in quiescent muscle stem cells in response to DNA:RNA hybrids, and this activity maintains quiescence by ensuring degradation of key cell-cycle transition factors by the E3 ubiquitin ligase cyclin F–SCF complex. This is critical for understanding how stem cells regulate a state of prolonged and reversible cell-cycle arrest and how genome integrity is maintained over time. Together, these studies offer a unique picture of a molecular mechanism controlling stem cell quiescence.Keywords
Funding Information
- Human Frontier Science Program (LT000028/2015-L)
- HHS | National Institutes of Health (P01 AG036695)
- HHS | National Institutes of Health (R01 AR073248)
- HHS | National Institutes of Health (R01 ES016486)
- U.S. Department of Veterans Affairs (I01BX002324)
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