Mikkel Christian Larsen

Introduction: Ingested foreign bodies are common in otolaryngology and gastrointestinal surgery, with grill brush bristles posing different risks. This case report describes a small bowel perforation after ingestion of a grill brush bristle. This is an extremely rare complication. Case report: A 51-year-old woman presented with two days of left-sided abdominal pain. Lab tests showed elevated CRP, and a CT scan indicated inflammation and a possible foreign body. Diagnostic laparoscopy revealed a wire bristle perforating the small intestine, leading to resection and anastomosis. The bristle was likely from a grill brush. The patient recovered well and was discharged three days later. Discussion: Grill brush bristles can detach, be ingested, and cause gastrointestinal perforation. Symptoms are often delayed, complicating diagnosis. CT imaging and laparoscopy were key in identifying and treating this case. Increased public awareness of the risks and promotion of safer grill-cleaning tools could reduce such incidents. Conclusion: Ingested grill brush bristles can cause serious complications. Early recognition, imaging, and timely surgery are essential, along with public education to prevent future cases. Highlights:

Summary: A 67‐year‐old woman with no history of cardiovascular disease, undergoing an elective laparoscopic cholecystectomy, experienced severe bradycardia and cardiac arrest immediately following an alveolar recruitment manoeuvre under general anaesthesia. Prompt cardiopulmonary resuscitation restored cardiac output within 2–3 min. Postoperatively, she remained stable and was discharged following 24 h of monitoring. The cardiac arrest was likely triggered by vagal nerve stimulation and activation of intrinsic cardiac reflexes by the alveolar recruitment manoeuvre. The event emphasises a rare, but significant, risk of the routine management of pulmonary atelectasis.

Significance: The replication stress response protein, ATR, is active in quiescent muscle stem cells in response to DNA:RNA hybrids, and this activity maintains quiescence by ensuring degradation of key cell-cycle transition factors by the E3 ubiquitin ligase cyclin F–SCF complex. This is critical for understanding how stem cells regulate a state of prolonged and reversible cell-cycle arrest and how genome integrity is maintained over time. Together, these studies offer a unique picture of a molecular mechanism controlling stem cell quiescence.