Na-K-ATPase in nephron segments of rats developing spontaneous hypertension

Authors:
  • LGL. C. Garg
    L. C. Garg
  • NNN. Narang
    N. Narang
  • SMS. McArdle
    S. McArdle
  • BFBen Fogelgren
    Ben Fogelgren
  • SYShiming Yang
    Shiming Yang
  • ISIan C. Sharp
    Ian C. Sharp
  • OHOdaro J. Huckstep
    Odaro J. Huckstep
  • WMWenbin Ma
    Wenbin Ma
  • SSS. J. Somponpun
    S. J. Somponpun
  • ECEdward C. Carlson
    Edward C. Carlson
  • CUCatherine F. T. Uyehara
    Catherine F. T. Uyehara
  • SLScott Lozanoff
    Scott Lozanoff
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Abstract
Na-K-ATPase activity was determined in seven specific nephron segments of 5- and 12-wk-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) controls. The enzyme activity in proximal convoluted tubule (PCT) and proximal straight tubule (PST) was significantly higher in 5-wk-old SHR than in WKY. However, Na-K-ATPase activity in medullary thick ascending limb (MTAL), cortical thick ascending limb (CTAL), and distal convoluted tubule (DCT) was significantly lower in 5-wk-old SHR than in WKY. There were no significant differences in the enzyme activity in PCT, PST, MTAL, CTAL, and DCT in 12-wk-old SHR and WKY. Furthermore, there were no significant differences in Na-K-ATPase activity in collecting duct segments of 5- or 12-wk-old SHR and age-matched WKY. The possible role of the abnormal pattern of Na-K-ATPase activity in PCT, PST, MTAL, CTAL, and DCT in 5-wk-old SHR in generation of hypertension in this strain remains to be determined.

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