Cutibacterium acnes Induces the Expression of Immunosuppressive Genes in Macrophages and is Associated with an Increase of Regulatory T-Cells in Prostate Cancer

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Abstract
In an immune suppressive tumor microenvironment constituted by immunosuppressive cells and immunosuppressive mediators, tumors may improve their ability to give rise to a clinically relevant cancer. In the present study, we found that C. acnes might contribute to an immunosuppressive environment by recruiting regulatory T cells and by increasing the expression of immunosuppressive mediators such as PD-L1, CCL17, and CCL 18.
Funding Information
  • Maud och Birger Gustavssons Stiftelser (Dnr 13/2018)
  • Lions Cancer Foundation (2018)
  • Örebro County Council Research Committee
  • Foundation for Medical Research at Örebro University Hospital

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