Advanced myocardial characterization in hypertrophic cardiomyopathy: feasibility of CMR-based feature tracking strain analysis in a case-control study

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Abstract
Objectives This study aimed to evaluate the feasibility and reproducibility of using cardiovascular magnetic resonance feature tracking (CMR-FT) for analysis of bi-ventricular strain and strain rate (SR) in hypertrophic cardiomyopathy (HCM) patients as well as to explore the correlation between right ventricular (RV) and left ventricular (LV) deformation. Methods A total of 60 HCM patients and 48 controls were studied. Global and segmental peak values of bi-ventricular longitudinal, circumferential, radial strain, and systolic SR were analyzed. Pearson analysis was performed to investigate the correlation of RV and LV deformation. Intra-observer and inter-observer reproducibility were also assessed. Results LV mass in the HCM group was significantly higher than that in the control group. LV end-systolic and end-diastolic volume and RV end-systolic and end-diastolic volume in the HCM group were all significantly lower than the correlated parameters in the control group (p < 0.001, respectively), whereas no statistical difference was found in ejection fraction (p > 0.05). Global longitudinal strain (GLS), global longitudinal strain rate (GLSR), global circumferential strain (GCS), global circumferential strain rate (GCSR), global radial strain (GRS), and global radial strain rate (GRSR) of the LV and RV were all significantly lower than the control group, and segmental strain and SR were also true (p < 0.001, respectively). Bi-ventricular strain and SR measurements were highly reproducible at both intra- and inter-observer levels. Additionally, Pearson analysis showed RV GCS, GLS, and GRS positively correlated with LV GCS, GLS, and GRS (r = 0.713, p < 0.001; r = 0.728, p < 0.001; r = 0.730, p < 0.001, respectively). Conclusions CMR-FT is a promising approach to analyze impairment of global and segmental myocardium deformation in HCM patients non-invasively and quantitatively. Key Points • CMR-FT allows for advanced myocardial characterization with high reproducibility. • As compared with controls, HCM patients have significant differences in CMR-FT strain analysis while ejection fraction was similar. • CMR-FT may serve as an early biomarker of HCM in subjects at risk.
Funding Information
  • Innovative Research Group Project of the National Natural Science Foundation of China (81571740)
  • Scientific Research Grant of Heilongjiang Province Natural Science Foundation for Returned Chinese Scholars (LC201436)
  • Postdoctoral Special Scientific Research Grant of Heilongjiang Provincial Government (LBH-Q17104)
  • Distinguished Young Scientist Funding of Harbin Medical University Affiliated Tumor Hospital (JCQN2019-02)
  • Key Project of the Climbing Funding of the National Cancer Center (NCC201808B019)
  • Youth Scientific Research Grant of Heilongjiang Province Natural Science Foundation (QC2015127)
  • Medical Scientific Research Foundation of Heilongjiang Province Health Department (2014-312)
  • Natural Science Foundation of 2nd Affiliated Hospital Harbin Medical University (KTBS2015-26)

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