Colonoscopy-Based Intramucosal Transplantation of Cancer Cells for Mouse Modeling of Colon Cancer and Lung Metastasis
Open Access
- 16 August 2021
- journal article
- research article
- Published by Taylor & Francis in BioTechniques
- Vol. 71 (3) , 9
Abstract
The conventional orthotopic/xenograft models or genetically engineered murine models of colon cancer (CRC) are limited in their scope for a true understanding of tumor growth, progression and event... Method summary This study describes a procedure for murine modeling of CRC progression and metastasis to the lungs by colonoscopic-guided implantation of colon cancer cells into the host colonic mu... Graphical abstractKeywords
Funding Information
- National Institute of Cancer R21 grant funding (CA216746)
- VA-Merit Award (BX002086, BX002761)
- National Institute of Health (DK124095)
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