Discovery, SAR, and molecular basis of (R)-1-((3R,4S)-3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-3-(3-fluorophenyl)-2-methylpropan-1-one as a novel potent analgesic

This publication has 36 references indexed in Scilit:

• Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail
  CNS Drugs, 2025
• Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-explored, active-controlled, phase II/III clinical trial
  Pharmacological Research, 2025
• Discovery of N′-benzyl-3-chloro-N-((1S,3R,4R)-3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)cyclohexyl)benzenesulfonamide as a novel selective KOR ligand
  European Journal of Medicinal Chemistry, 2024
• Molecular Mechanism of Action of GPR91 Agonists and Antagonists: Insights from Molecular Dynamics Simulation
  Chemical Research in Chinese Universities, 2024
• Flexible scaffold-based cheminformatics approach for polypharmacological drug design
  Cell, 2024
• Structures of the entire human opioid receptor family
  Cell, 2023
• Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
  European Journal of Medicinal Chemistry, 2020
• Opioid induced nausea and vomiting
  European Journal of Pharmacology, 2014
• Why Patients Visit Their Doctors: Assessing the Most Prevalent Conditions in a Defined American Population
  Mayo Clinic Proceedings, 2013
• Evaluation of N-substitution in 6,7-benzomorphan compounds
  Bioorganic & Medicinal Chemistry, 2010