Supplemental Figure 5 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer

Authors:
Open Access
Publisher website
Google Scholar
Abstract
MTT growth assay of single treatments with Chk1i (treated with concentrations ranging from 12.5 nM - 5 µM) and Olap (treated with concentrations ranging from 0.25 µM- 64 µM) in WT, Y537S and Y537C models Percent viability was normalized to untreated controls. Graphs represent mean + standard deviation with minimum n=4 at each concentration. IC50s were determined using CompuSyn. Statistics comparing %viability of ESR1m versus WT cells at indicated concentrations are denoted by asterisks in corresponding colors (Y537S=red, Y537C=gold). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001