An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite
- 20 December 2022
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 66 (12) , e0026922
Abstract
We generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with drug resistance were detected in ResCQ clones.Keywords
Funding Information
- The Scientific and Technological Research Council of Turkey (119Z409)
- NIH-NIAID (1R21AI111058-01A1)
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