Synthesis of Thienyl Polycyclic Fused Indoles Based on the Indium Catalyzed Prins/Friedel‐Crafts Tandem Reaction
Authors:
- 11 May 2023
- journal article
- research article
- Published by Wiley in Asian Journal of Organic Chemistry
- Vol. 12 (6)
Abstract
An indium catalyzed Prins/Friedel‐Crafts tandem cyclization reaction has been developed. This reaction provides an efficient and practical method to construct a variety of polycyclic indole frameworks with high diastereoselectivity and good functional group tolerance (30 examples, up to 98% yield with >95 : 5 dr). The resulting products are easily accessible for further chemical transformations.Keywords
Funding Information
- National Natural Science Foundation of China (91956103)
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