Structured inhibitory activity dynamics in new virtual environments

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Inhibition plays a powerful role in regulating network excitation and plasticity; however, the activity of defined interneuron types during spatial exploration remain poorly understood. Using two-photon calcium imaging, we recorded hippocampal CA1 somatostatin- and parvalbumin-expressing interneurons as mice performed a goal-directed spatial navigation task in new visual virtual reality (VR) contexts. Activity in both interneuron classes was strongly suppressed but recovered as animals learned to adapt the previously learned task to the new spatial context. Surprisingly, although there was a range of activity suppression across the population, individual somatostatin-expressing interneurons showed consistent levels of activity modulation across exposure to multiple novel environments, suggesting context-independent, stable network roles during spatial exploration. This work reveals population-level temporally dynamic interneuron activity in new environments, within which each interneuron shows stable and consistent activity modulation.
All Related Versions
Funding Information
  • McDonnell Center for Systems Neuroscience
  • McDonnell Center for Cellular and Molecular Neurobiology
  • Washington University in St. Louis (Cognitive, Computational, Systems Neuroscience Pathway (Graduate Student Fellowship))

This publication has 92 references indexed in Scilit: