Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition
- 8 January 2016
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 351 (6269) , aaa5694
Abstract
Fine-tuned information flow in the brain: In addition to providing well-characterized excitatory inputs, the entorhinal cortex also sends long-range inhibitory projections to the hippocampus. Basu et al. described this input in detail and characterized its role for learning and memory. Multimodal sensory stimuli activate long-range inhibitory input in vivo. This input enables precisely timed information transfer within the cortico-hippocampal circuit. In this way, long-range inhibitory projections play an important role in providing specificity of fear conditioning, and thus help prevent overgeneralization. Science , this issue p. 10.1126/science.aaa5694Keywords
Funding Information
- NARSAD
- National Institute of Mental Health (NIMH)
- NIMH (1R01MH10051, 1R01MH100631)
- Searle Scholars Program
- Human Frontier Science Program
- McKnight Memory and Cognitive Disorders Award
- National Institute of Neurological Disorders and Stroke (R01NS036658)
- NIH
- Howard Hughes Medical Institute
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