Ph3P═O-Catalyzed Reductive Deoxygenation of Alcohols
- 11 October 2024
- journal article
- editorial
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 89 (21) , 16022-16027
Abstract
Reductive deoxygenation of alcohols is particularly challenging because of the high bond dissociation energy of the C-OH bond and the poor leaving ability of the hydroxyl group. Herein we describe a Ph3P═O-catalyzed reductive deoxygenation of benzyl alcohols with PhSiH3 under an air atmosphere within 30 min of reaction time. The use of catalytic loading of Ph3P═O enhances the practicality of this protocol.Keywords
Funding Information
- National Key Research and Development Program of China (2021YFF0701700)
- Science and Technology Commission of Shanghai Municipality (22ZR1423600)
- National Natural Science Foundation of China (21991122, 22271181)
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