Synthesis of 5-[3-amino-imidazo[1,2- a ]pyridin-6-yl]pyridin-2-ones and derivatives through the combination of palladium-catalyzed cross-coupling and GBB multi-component reactions
Open Access
- 29 October 2026
- journal article
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 16 (47) , 61780-61783
Abstract
A combined Suzuki-type palladium-catalyzed cross-coupling and Groebke–Blackburn–Bienaymé (GBB) multicomponent strategy enabled the synthesis of novel 5-[3-amino-imidazo[1,2- a ]pyridin-6-yl]pyridin-2-ones and 3,5-disubstituted pyridin-2-ones.Keywords
This publication has 23 references indexed in Scilit:
- Recent Advances in Green Catalytic Multicomponent Reactions for Sustainable SynthesisChemistrySelect, 2026
- Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic AdvancementsJournal of Medicinal Chemistry, 2024
- Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitorsEuropean Journal of Medicinal Chemistry, 2022
- Protecting Group‐Controlled Regioselective Synthesis for Unsymmetrical 3,5‐Disubstituted PyridonesAdvanced Synthesis & Catalysis, 2022
- Recent Advances in the Synthesis of Imidazo[1,2‐ a ]pyridines: A Brief ReviewChemistrySelect, 2022
- Recent Progress in Metal-Free Direct Synthesis of Imidazo[1,2-a]pyridinesACS Omega, 2021
- Identification and Structure–Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)ACS Chemical Neuroscience, 2019
- SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenaseBioorganic & Medicinal Chemistry Letters, 2012
- A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-AminoimidazolesAngewandte Chemie International Edition, 1998
- Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensationTetrahedron Letters, 1998