On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide
Open Access
- 3 April 2023
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 120 (15)
Abstract
Food intake is regulated by internal state. This function is mediated by hormones and neuropeptides, which are best characterized in popular model species. However, the evolutionary origins of such feeding-regulating neuropeptides are poorly understood. We used the jellyfishCladonemato address this question. Our combined transcriptomic, behavioral, and anatomical approaches identified GLWamide as a feeding-suppressing peptide that selectively inhibits tentacle contraction in this jellyfish. In the fruit flyDrosophila, myoinhibitory peptide (MIP) is a related satiety peptide. Surprisingly, we found that GLWamide and MIP were fully interchangeable in these evolutionarily distant species for feeding suppression. Our results suggest that the satiety signaling systems of diverse animals share an ancient origin.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology (KAKENHI 20K15838)
- Ministry of Education, Culture, Sports, Science and Technology (KAKENHI 17F17092)
- Ministry of Education, Culture, Sports, Science and Technology (KAKENHI 20H00519)
- Tohoku University Research Program "Frontier Research in Duo" (N/A)
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