Optimal Detection of Latent Mycobacterium tuberculosis Infection by Combined Heparin-Binding Hemagglutinin (HBHA) and Early Secreted Antigenic Target 6 (ESAT-6) Whole-Blood Interferon Gamma Release Assays
Authors:
Open Access
- 18 May 2022
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 60 (5) , e0244321
Abstract
Optimal detection of latent tuberculosis (TB) infection (LTBI) remains a challenge, although it is essential to reach the goal of TB elimination. Our objective was to develop and clinically evaluate a user-friendly, 24-h, whole-blood (WB) interferon gamma (IFN-γ) release assay (IGRA) improving the detection of LTBI, compared to available tests.Keywords
Funding Information
- Tuberculosis Vaccine Initiative (NORAD)
- INNOV-IRIS Brussels
- European Commission (HEALTH-2009-2.3.2-2)
- Fonds De La Recherche Scientifique - FNRS (PDR T.0147.13)
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