RA-XTNet: A Novel CNN Model to Predict Rheumatoid Arthritis from Hand Radiographs and Thermal Images: A Comparison with CNN Transformer and Quantum Computing

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Abstract
The aim and objective of the research are to develop an automated diagnosis system for the prediction of rheumatoid arthritis (RA) based on artificial intelligence (AI) and quantum computing for hand radiographs and thermal images. The hand radiographs and thermal images were segmented using a UNet++ model and color-based k-means clustering technique, respectively. The attributes from the segmented regions were generated using the Speeded-Up Robust Features (SURF) feature extractor and classification was performed using k-star and Hoeffding classifiers. For the ground truth and the predicted test image, the study utilizing UNet++ segmentation achieved a pixel-wise accuracy of 98.75%, an intersection over union (IoU) of 0.87, and a dice coefficient of 0.86, indicating a high level of similarity. The custom RA-X-ray thermal imaging (XTNet) surpassed all the models for the detection of RA with a classification accuracy of 90% and 93% for X-ray and thermal imaging modalities, respectively. Furthermore, the study employed quantum support vector machine (QSVM) as a quantum computing approach which yielded an accuracy of 93.75% and 87.5% for the detection of RA from hand X-ray and thermal images. In addition, vision transformer (ViT) was employed to classify RA which obtained an accuracy of 80% for hand X-rays and 90% for thermal images. Thus, depending on the performance measures, the RA-XTNet model can be used as an effective automated diagnostic method to diagnose RA accurately and rapidly in hand radiographs and thermal images.

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