Design, synthesis, and biological evaluation of indole-modified tamoxifen relatives as potent anticancer agents
- 29 May 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Medicinal Chemistry
- Vol. 14 (7) , 1362-1376
Abstract
Modulation of existing drugs is an attractive strategy to improve the efficacy of cancer therapies. We modulated tamoxifen (TMX) by replacing theC-phenyl ring in its backbone with an indole or oxindole and analyzed its anticancer potential.Keywords
Funding Information
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (121Z116, BİDEB 2211-C)
- Yükseköğretim Kurulu (100/2000)
This publication has 52 references indexed in Scilit:
- Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory FactorCell Reports, 2013
- Role of Estrogen Receptor Signaling in Breast Cancer MetastasisInternational Journal of Breast Cancer, 2011
- microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cellsOncology Reports, 2011
- Practical Synthesis of FEt-penta-cyclofenil and Its Derivatives for Potential PET ImagingSynthetic Communications, 2010
- Two New Indole Alkaloids from the Marine‐Derived Bacterium Aeromonas sp. CB101Helvetica Chimica Acta, 2010
- Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and AnxietyChemical Reviews, 2010
- Triple-Negative Breast Cancer: Clinical Features and Patterns of RecurrenceClinical Cancer Research, 2007
- Practical Methodologies for the Synthesis of IndolesChemical Reviews, 2006
- Antiestrogens and Selective Estrogen Receptor Modulators as Multifunctional Medicines. 2. Clinical Considerations and New AgentsJournal of Medicinal Chemistry, 2003
- Vibrindole A, a Metabolite of the Marine Bacterium, Vibrio parahaemolyticus, Isolated from the Toxic Mucus of the Boxfish Ostracion cubicusJournal of Natural Products, 1994