BMPR2 expression is suppressed by signaling through the estrogen receptor
Authors:
- Eric D AustinEAEric D Austin
- Rizwan HamidRHRizwan Hamid
- Anna R HemnesAHAnna R Hemnes
- James E LoydJLJames E Loyd
- Tom BlackwellTBTom Blackwell
- Chang YuCYChang Yu
- John A Phillips IiiJIJohn A Phillips Iii
- Radhika GaddipatiRGRadhika Gaddipati
- Santhi GladsonSGSanthi Gladson
- Everett GuEGEverett Gu
- James WestJWJames West
- Kirk B LaneKLKirk B Lane
Open Access
- 1 January 2012
- journal article
- Published by Springer Nature in Biology of Sex Differences
- Vol. 3 (1) , 6
Abstract
Studies in multiple organ systems have shown cross-talk between signaling through the bone morphogenetic protein receptor type 2 (BMPR2) and estrogen pathways. In humans, pulmonary arterial hypertension (PAH) has a female predominance, and is associated with decreased BMPR2 expression. The goal of this study was to determine if estrogens suppress BMPR2 expression.Keywords
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