Influence of optical aberrations on depth-specific spatial frequency domain techniques

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Abstract
Spatial frequency domain techniques use spatially modulated illumination patterns to quantify absorption and scattering properties of tissue and other diffusive media across visible and/or near-infrared ranges.1 – 4 These techniques can be implemented in a variety of ways such as spatial frequency domain imaging (SFDI)2 or spatial frequency domain spectroscopy (SFDS).3 Through the quantification of these optical properties, SFDI/S has demonstrated the potential to non-invasively assess skin cancers,5,6 wound severity,7,8 and tissue structure and viability9,10 in the skin. In many of these clinical applications, such as burn wound assessment and melanin quantification, depth sensitivity and subsurface discrimination approaches enabled by SFDI/S are critical features toward accurate characterization of specific tissue volumes.11 – 15

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