Evaluation of the phytochemical screening, antioxidant, cytotoxic, and antimicrobial activities of leaves of methanolic extract of Baccaurea motleyana (mull. Arg.)

Authors:
  • AAAtiq Md. Ashhab
    Atiq Md. Ashhab
  • SASohan Md. Ahmed
    Sohan Md. Ahmed
Open Access
Publisher website
Google Scholar
Abstract
The current study targeted the methanolic extract of Baccaurea motleyana to investigate the phytochemical, Antioxidant, Cytotoxic and Antimicrobial effects. The phytochemical analysis revealed promising amounts of total phenols, flavonoids, and proanthocyanidins, measured at 134.28 ? 5.59 mg Gallic acid/g, 176.92 ? 4.12 mg Catechin/g, and 145.25 ? 4.44 mg Catechin/g, respectively. For determination of antioxidant effect using TAC and FRAP assays method, methanolic extract of Baccaurea motleyana leaf represented gradually increased reducing capacity in a dose-dependent manner, as well as notable free radical scavenging activity in the DPPH and ABTS assays. The cytotoxicity assay demonstrated significant activity with LC50 found 628.56 ?g/ml. The extract also exhibited antimicrobial activity against Staphylococcus aureus, and Shigella boydii, with inhibition zone of 12.9 ? 0.20 mm and 3.8 ? 0.29 mm at a concentration of 40?g, respectively. These findings suggest that methanolic extracts have significant amounts of phytochemical and antioxidant effects that help to fight against the free radical which could be used as a therapy for multifactorial illnesses. The result of the present study is on antimicrobial effects that could be potentially useful for the development of therapeutic agents against bacterial infections. However, the cytotoxic assay requires further investigation to determine the appropriate medicinal dose and to better understand the specific mechanisms of action.

This publication has 55 references indexed in Scilit: