Supplemental Figure 12 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer

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Abstract
Lower concentrations of Olaparib treatment inhibit PARylation but do not show effect on estrogen regulated proteins in ESR1m models Western blot analysis of WT or Y537S cells after 48 hours of estrogen deprivation in charcoal stripped serum media followed by Olap (300 nM, 1 µM, 2 µM) treatment harvested at indicated timepoints in hours. Densitometry is relative to untreated controls within each cell line due to differences in protein expression between cell lines. Densitometry is indicated under each band and was normalized to lane 1 WT control.