Iron‐Catalyzed Direct C3−H Trifluoromethylthiolation of Quinoxalin‐2(1H)‐ones
- 20 December 2023
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 366 (2) , 214-219
Abstract
An iron‐catalyzed direct C3−H radical trifluoromethylthiolation of quinoxalin‐2(1H)‐ones has been developed. This protocol uses earth‐abundant FeSO4 ⋅ 7H2O as the catalyst, and AgSCF3 as the trifluoromethylthiolating reagent to provide various SCF3‐containing quinoxalin‐2(1H)‐one derivatives in 26–88% yields. Preliminary mechanistic investigations indicate that the reaction proceeds through a radical pathway.Keywords
Funding Information
- National Natural Science Foundation of China (21172200)
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