Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†
Author:
- Paul GreengardPGPaul Greengard
- 11 March 1976
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 260 (5547) , 101-108
Abstract
The postsynaptic actions of some neurotransmitters may be mediated through cyclic nucleotides and cyclic nucleotide-dependent phosphorylation of specific membrane proteins in postsynaptic cells. In addition to providing a molecular basis for the actions of several neurotransmitters and of certain drugs affecting behaviour, the model suggests a mechanism by which neurotransmitter signals may be converted into electrophysiological responses in postsynaptic cells.Keywords
This publication has 82 references indexed in Scilit:
- Evidence for the lack of direct phosphorylation of bovine caudate tyrosine hydroxylase following activation by exposure to enzymatic phosphorylating conditionsBiochemical and Biophysical Research Communications, 1975
- Measurements of adenosine 3′:5′‐cyclic monophosphate and membrane potential in neuroblastoma X glioma hybrid cells: Opiates and adrenergic agonists cause effects opposite to those of postaglandin E1FEBS Letters, 1975
- Effects of dopamine-like drugs on rat striatal adenyl cyclase have implications for CNS dopamine receptor topographyNature, 1974
- Drugs, Neurotransmitters, and SchizophreniaScience, 1974
- Do cyclic nucleotides promote the trans-synaptic induction of tyrosine hydroxylase?Life Sciences, 1974
- Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenateNature, 1974
- Octopamine-Sensitive Adenylate Cyclase: Evidence for a Biological Role of Octopamine in Nervous TissueScience, 1973
- A protein kinase activity from rat cerebellum stimulated by guanosine-3′:5′-monophosphateBiochemical and Biophysical Research Communications, 1972
- The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse cerebral cortex and cerebellumBiochemical and Biophysical Research Communications, 1970
- The formation of synaptic junctions in developing rat brain: A quantitative electron microscopic studyBrain Research, 1967