Electrochemical trifluoromethylation of alkenyl oximes for the synthesis of isoxazolines and cyclic nitrones via radical annulation
- 24 June 2025
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 23 (28) , 6808-6813
Abstract
An oxidant-free electrochemical method for synthesizing CF3-substituted isoxazolines and nitrones via radical cyclization of alkenyl oximes with CF3SO2Na, exhibiting broad substrate scope and high functional group tolerance.Keywords
Funding Information
- National Natural Science Foundation of China (22408142)
- Lishui University (6604CJF01Z)
This publication has 54 references indexed in Scilit:
- Photochemical and Electrochemical Synthesis of Oxazoles and Isoxazoles: An UpdateAdvanced Synthesis & Catalysis, 2024
- Electrochemical Trifluoromethylalkoxylation of Endocyclic Enamides in Batch and FlowAdvanced Synthesis & Catalysis, 2024
- Recent Advances in Pd‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reactions with Triflates or NonaflatesAdvanced Synthesis & Catalysis, 2023
- Radical Cascade Reactions of β,γ‐Unsaturated Hydrazones/OximesAdvanced Synthesis & Catalysis, 2021
- Progress in Electrochemical Trifluoromethylation ReactionsAdvanced Synthesis & Catalysis, 2020
- Electrochemical Decarboxylative Trifluoromethylation of α, β‐Unsaturated Carboxylic Acids with CF3SO2NaChemCatChem, 2019
- A Copper Catalyst with a Cinchona‐Alkaloid‐Based Sulfonamide Ligand for Asymmetric Radical Oxytrifluoromethylation of Alkenyl OximesAngewandte Chemie International Edition, 2018
- Modern Electrochemical Aspects for the Synthesis of Value‐Added Organic ProductsAngewandte Chemie International Edition, 2018
- Direct Trifluoromethylthiolation and Perfluoroalkylthiolation of C(sp2)-H Bonds with CF3SO2Na and RfSO2NaAngewandte Chemie International Edition, 2015
- Application of Langlois’ Reagent in Trifluoromethylation ReactionsAdvanced Synthesis & Catalysis, 2014