Jiangfei Chen

The past decade has witnessed remarkable advances in light‐induced, three‐component ketone synthesis, yet a systematic and updated overview remains absent since the last relevant review in 2020. This review fills that gap by providing a comprehensive survey of the field from 2015 to 2025, with a particular focus on substrate diversity and mechanistic analysis. We organize the literature by the carbon skeletons, including alkenes, alkynes, simple ketones, phenols, and [1.1.1]propellane. We also systematically analyze the role of carbonyl oxygen sources, such as O ₂ /air, H ₂ O, H ₂ O ₂ , TBHP, CO, aldehydes, and ketones. By emphasizing mechanistic details for each transformation, this review not only consolidates scattered knowledge but also aims to guide future reaction design and inspire new synthetic strategies in sustainable ketone synthesis.

Light‐induced three‐component reactions have emerged as a powerful strategy for the sustainable synthesis of organosulfur compounds. They offer many advantages, such as readily available starting materials, mild reaction conditions, high atom economy, and simplified operational procedures. This review summarizes advances over the past decade in the construction of thioethers, thiocyanates, thioesters, thiolates, sulfoxides, sulfones, sulfonyl fluorides, and other sulfur‐containing frameworks.

Catalyst‐free, light‐induced three‐component reactions can conveniently synthesize complex compounds. These elements align with the principles of green chemistry and have been research hotspots. Their combination not only simplifies the reaction but also avoids metal residues in the products. Previous reviews have focused mainly on single reactions, with little attention to the combination of all three. This review mainly focuses on recent advances (2015–2025) categorized by product types. Mechanisms and the roles of added reagents will be discussed. Key intermediates can be generated via electron donor–acceptor (EDA) complexes, single‐electron transfer, halogen atom transfer, hydrogen atom transfer, homolysis, singlet oxygen ( ¹ O ₂ ), triplet diradical species, carbenes, etc. Reactions via EDA complexes, which proceed under visible light, have attracted the most attention due to their practicality and simplicity. The discussion covers strategies for constructing CC, CN, CO, CS, and CSe bonds. We hope this review will be helpful for future research in this area.

A lithium tert-butoxide-mediated transesterification of NHPI esters with oximes enables efficient oxime ester formation under mild, metal-free conditions. DFT studies reveal a lithium-assisted chelation-driven substitution pathway.

This review discusses the electrochemical applications of inorganic compounds as starting materials in organic synthesis (2013–2024). In some cases, additional electrolytes are unnecessary due to the presence of inorganic substrates.

The field of radical-mediated functionalization of N-arylacrylamides has experienced considerable advancements in recent years, particularly in the domain of oxidative radical difunctionalization reactions employing carbon radical reagents. This approach provides a powerful and versatile strategy for the concurrent introduction of two distinct functional groups across the double bond of N-arylacrylamides, facilitating the rapid construction of complex molecular architectures. This review aims to summarize the diverse strategies for inducing intramolecular transformations of N-arylacrylamides using various carbon radical reagents, including methods initiated by photonic, thermal, or electrochemical processes, which have been extensively investigated by researchers.

An oxidant-free electrochemical method for synthesizing CF₃-substituted isoxazolines and nitrones via radical cyclization of alkenyl oximes with CF₃SO₂Na, exhibiting broad substrate scope and high functional group tolerance.