Effect of non-invasive ventilation and high-flow nasal cannula on hospital mortality in COVID-19-induced acute respiratory failure: a meta-analysis
Authors:
- Jakson Henrique SilvaJSJakson Henrique Silva
- Anna Luísa Araújo BritoABAnna Luísa Araújo Brito
- Redha TaiarRedha Taiar
- Bruno Amorim MoraesBMBruno Amorim Moraes
- Anderson Brasil XavierAXAnderson Brasil Xavier
- Wagner Souza LeiteWLWagner Souza Leite
- Maria das Graças Rodrigues de AraújoMAMaria das Graças Rodrigues de Araújo
- Daniella Cunha BrandãoDBDaniella Cunha Brandão
- Armele de Fátima Dornelas AndradeAAArmele de Fátima Dornelas Andrade
- Shirley Lima CamposSCShirley Lima Campos
Open Access
- 17 December 2025
- journal article
- research article
- Published by Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein in Einstein (São Paulo)
- Vol. 24, eRW0695
Abstract
Background Non-invasive respiratory support strategies, such as high-flow nasal cannula therapy and non-invasive ventilation, were widely employed during the coronavirus disease 2019 (COVID-19) pandemic, yet their comparative effectiveness remains uncertain. Objective To compare the effects of high-flow nasal cannula therapy, non-invasive ventilation, and conventional oxygen therapy on intubation rates and hospital mortality in adults with COVID-19-related acute respiratory failure. Methods A systematic review and meta-analysis was conducted following PRISMA and Cochrane guidelines, with searches performed in nine databases forKeywords
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