Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B against Cryptococcus neoformans
Authors:
- M. E. KlepserMKM. E. Klepser
- E. J. WolfeEWE. J. Wolfe
- M. A. PfallerMPM. A. Pfaller
Open Access
- 1 March 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 41 (3) , 397-401
Abstract
The activity of fluconazole and amphotericin B against three isolates of Cryptococcus neoformans was evaluated, with fluconazole and amphotericin B MICs of 2.0-4.0 mg/L and 1.0 mg/L respectively, using time-kill curve methods. Fluconazole was fungistatic against all isolates tested ( or = 99.9% decrease in cfu from initial inoculum). Both the rate and the extent of amphotericin B activity were enhanced when drug concentration was increased.Keywords
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