Supplemental Figure 9 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer

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Abstract
Western blot analysis of cell cycle checkpoint and DDR proteins in Y537S and Y537C cell line models control (Ctrl) vs 24 h treatment with 0.5 mM HU Cells were maintained in charcoal stripped serum media for 48 hours before harvest. Densitometry is indicated under each band and relative to WT cells after normalization to loading control (GAPDH). GAPDH densitometry is displayed relative to WT cells.