Application of Polymer‐Supported Triphenylphosphine and Microwave Irradiation to the Palladium‐Catalyzed Cyanation of Aryl Triflates
Authors:
- 1 February 2007
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 37 (3) , 431-438
Abstract
A variety of aryl nitriles were prepared in excellent yield from the palladium(II) acetate–catalyzed cross‐coupling of aryl triflates and zinc cyanide under microwave irradiation conditions. To facilitate purification, polymer‐supported triphenylphosphine was used as the palladium ligand. Comparison to the corresponding thermal conditions revealed much shorter reaction times with comparable yields.Keywords
This publication has 25 references indexed in Scilit:
- TBAF-Catalyzed Synthesis of 5-Substituted 1H-Tetrazoles under Solventless ConditionsThe Journal of Organic Chemistry, 2004
- Rapid, Easy Cyanation of Aryl Bromides and Chlorides Using Nickel Salts in Conjunction with Microwave PromotionThe Journal of Organic Chemistry, 2003
- A Direct Synthesis of Aromatic Nitriles from Methylaromatic Compounds by Ammoxidation on DC-108 CatalystSynthetic Communications, 1999
- 11-Substituted (R)-Aporphines: Synthesis, Pharmacology, and Modeling of D2Aand 5-HT1AReceptor InteractionsJournal of Medicinal Chemistry, 1996
- Preparation of optically active binaphthylmonophosphines (MOP's) containing various functional groupsTetrahedron, 1994
- 4-Hydroxythiazole inhibitors of 5-lipoxygenaseJournal of Medicinal Chemistry, 1991
- An efficient synthesis of the novel triazoloquinazoline adenosine antagonist, CGS 15943Journal of Heterocyclic Chemistry, 1990
- Functionalized oxazoles from rhodiumi-catalyzed reaction of dimethyl diazomalonate with nitrilesTetrahedron Letters, 1986
- Synthetic reactions in polyethylene glycol. Diazotization and sandmeyer reactions of anilines in polyethylene glycol–methylene dichlorideJournal of the Chemical Society, Chemical Communications, 1984
- Das am Ringkohlenstoff gebundene Halogen und sein Ersatz durch andere Substituenten. I. Mitteilung: Ersatz des Halogens durch die CarboxylgruppeBerichte der deutschen chemischen Gesellschaft (A and B Series), 1919