Neprylisin decreases uniformly in Alzheimer's disease and in normal aging
Authors:
- Roberta RussoRRRoberta Russo
- Roberta BorghiRBRoberta Borghi
- William MarkesberyWMWilliam Markesbery
- Massimo TabatonMTMassimo Tabaton
- Alessandra PicciniAPAlessandra Piccini
- 5 October 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (27) , 6027-6030
Abstract
The proteolysis of β‐amyloid (Aβ) requires neprylisin, an enzyme that has been shown as reduced in Alzheimer's disease (AD). We investigated whether a decrease in neprilysin levels contributes to the accumulation of amyloid deposits not only in AD but also in the normal aging. We analyzed neprilysin mRNA and protein levels in cerebral cortex from 10 cognitively normal elderly subjects with amyloid plaques (NA), 10 cases of AD, and 10 control cases free of amyloid plaques. We found a significant decrease in neprilysin mRNA levels in both AD and NA compared to control cases. Thereby, the defect of neprilysin appears to correlate with Aβ deposition but not with degeneration and dementia.Keywords
This publication has 25 references indexed in Scilit:
- Amyloid‐β in Alzheimer's disease: the horse or the cart? Pathogenic or protective?International Journal of Experimental Pathology, 2005
- Cytoplasmic domain of the ?-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug developmentJournal of Neuroscience Research, 2005
- Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluidNeuroscience Letters, 2003
- Oxidized neprilysin in aging and Alzheimer’s disease brainsBiochemical and Biophysical Research Communications, 2003
- The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to TherapeuticsScience, 2002
- Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathologyNeuroscience Research, 2002
- Metabolic Regulation of Brain Aβ by NeprilysinScience, 2001
- Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-AmyloidNeurobiology of Aging, 1998
- Immunochemical Evidence Supporting 2-Pentylpyrrole Formation on Proteins Exposed to 4-Hydroxy-2-nonenalChemical Research in Toxicology, 1996
- Membrane Localization of Endopeptidase‐24.11 and Peptidyl Dipeptidase A (Angiotensin Converting Enzyme) in the Pig Brain: A Study Using Subcellular Fractionation and Electron Microscopic ImmunocytochemistryJournal of Neurochemistry, 1992