Roberta Russo
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Roberta Russo has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
Alessandra Piccini
1 shared publicationMassimo Tabaton
1 shared publicationRoberta Borghi
1 shared publicationWilliam Markesbery
1 shared publication
Latest Publications
- 5 October 2005
- Published by Wiley in FEBS Letters
- Vol. 579 (27) , 6027-6030
Neprylisin decreases uniformly in Alzheimer's disease and in normal aging
The proteolysis of β‐amyloid (Aβ) requires neprylisin, an enzyme that has been shown as reduced in Alzheimer's disease (AD). We investigated whether a decrease in neprilysin levels contributes to the accumulation of amyloid deposits not only in AD but also in the normal aging. We analyzed neprilysin mRNA and protein levels in cerebral cortex from 10 cognitively normal elderly subjects with amyloid plaques (NA), 10 cases of AD, and 10 control cases free of amyloid plaques. We found a significant decrease in neprilysin mRNA levels in both AD and NA compared to control cases. Thereby, the defect of neprilysin appears to correlate with Aβ deposition but not with degeneration and dementia.
- 5 October 2005
- Published by Wiley in FEBS Letters
- Vol. 579 (27) , 6027-6030
Neprylisin decreases uniformly in Alzheimer's disease and in normal aging
The proteolysis of β‐amyloid (Aβ) requires neprylisin, an enzyme that has been shown as reduced in Alzheimer's disease (AD). We investigated whether a decrease in neprilysin levels contributes to the accumulation of amyloid deposits not only in AD but also in the normal aging. We analyzed neprilysin mRNA and protein levels in cerebral cortex from 10 cognitively normal elderly subjects with amyloid plaques (NA), 10 cases of AD, and 10 control cases free of amyloid plaques. We found a significant decrease in neprilysin mRNA levels in both AD and NA compared to control cases. Thereby, the defect of neprilysin appears to correlate with Aβ deposition but not with degeneration and dementia.