Revealing the Capability of an LMR Microfluidic Biosensor for Celiac Disease Diagnosis via Label-Free Detection of Antigliadin Antibodies

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Abstract
Celiac disease is a chronic autoimmune disorder triggered by gluten consumption which affects between 0.5% and 1% of the global population. Current diagnostic methods still require invasive procedures such as intestinal biopsy. LMR-based sensors hold great potential for the development of reliable and user-friendly devices for diagnosing this condition. In this work, an LMR planar microfluidic system is used to perform the label-free detection of different concentrations of anti-gliadin antibodies, one of the biomarkers of celiac disease, achieving a limit of detection of 1 μg/mL. The specificity of the sensor to the target analyte is also proved, and the validation of the biofunctionalization process is complemented with an AFM analysis

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