High Titers of Cytopathic Virus in Plasma of Patients with Symptomatic Primary HIV-1 Infection

Authors:
  • MSMichael S. Saag
    Michael S. Saag
  • WDW. Don Decker
    W. Don Decker
  • SCSherri Campbell-Hill
    Sherri Campbell-Hill
  • JRJoseph L. Roberson
    Joseph L. Roberson
  • PVPeter J. Veldkamp
    Peter J. Veldkamp
  • JKJohn C. Kappes
    John C. Kappes
  • GSGeorge M. Shaw
    George M. Shaw
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Abstract
Primary infection with the human immunodeficiency virus (HIV-1) frequently causes an acute, self-limited viral syndrome. To examine the relations among viral replication, the immune response of the host, and clinical illness during this initial phase of infection, we undertook a quantitative, molecular, and biologic analysis of infectious HIV-1 in the blood and plasma of three patients with symptomatic primary infection and of a sexual partner of one of them.

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