Ruthenium Nitrosyl Complexes with Bidentate Heterocycles and Chloride Ligands: Synthesis and Photorelease of NO
Preprint
- 2 July 2026
- preprint
- Published by MDPI AG in Preprints.org
Abstract
A series of novel complexes with the general formula [RuNO(L)Cl3], where L is a bidentate ligand (bpym, bpy, phen), was synthesized and characterized. The photochemical activity of fac-[RuNO(bpym)Cl3] (1), fac-[RuNO(phen)Cl3] (2), mer-[RuNO(phen)Cl3] (3), fac-[RuNO(bpy)Cl3] (4), mer-[RuNO(bpy)Cl3] (5) in DMSO was quantified under 450 nm irradiation using a flow-through system, allowing simultaneous IR and UV-Vis spectral monitoring. Quantum yields for photoinduced release of NO were determined as follows: 5.4 ± 0.5 % for fac-[RuNO(bpym)Cl3] (1); 0.8±0.1 % for fac-[RuNO(phen)Cl3] (2); 0.6±0.1 % for mer-[RuNO(phen)Cl3] (3); 3.7±0.1 % for fac-[RuNO(bpy)Cl3] (4); 2.1±0.1 % for mer-[RuNO(bpy)Cl3] (5). The product of photolysis of compound 5 in acetonitrile solution was isolated and structurally characterized as mer-[Ru(CH3CN)(bpy)Cl3] (6). Taking into account the presence of typical DNA intercalating ligands the complexes can be potentially exploited as photoNORMs.Keywords
All Related Versions
This publication has 26 references indexed in Scilit:
- Primary and secondary photochemical transformations of biologically active precursor - Nitro-Nitrosyl ruthenium complexJournal of Photochemistry and Photobiology A: Chemistry, 2019
- Mechanism and oxidation state involved in the nitric oxide (NO) photorelease in a terpyridine-bipyridine-based ruthenium nitrosyl complexInorganica Chimica Acta, 2018
- Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal PerspectiveEuropean Journal of Inorganic Chemistry, 2016
- Photochemical delivery of nitric oxideNitric Oxide, 2013
- Approaching tumour therapy beyond platinum drugsJournal of Inorganic Biochemistry, 2012
- KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor PatientsChemistry & Biodiversity, 2008
- Photoactive ruthenium nitrosyls: Effects of light and potential application as NO donorsCoordination Chemistry Reviews, 2008
- New features in the redox coordination chemistry of metal nitrosyls {M–NO+; M–NO; M–NO−(HNO)}Coordination Chemistry Reviews, 2007
- Photochemistry and Photophysics of Coordination Compounds: Overview and General Concepts2007
- Therapeutic potential of nitric oxide in cancerDrug Resistance Updates, 2006