The complex transcriptional landscape of the anucleate human platelet
Authors:
- Paul F BrayPaul F Bray
- Steven E McKenzieSteven E McKenzie
- Leonard C EdelsteinLeonard C Edelstein
- Srikanth NagallaSrikanth Nagalla
- Kathleen DelgrossoKathleen Delgrosso
- Adam ErtelAdam Ertel
- Joan KupperJoan Kupper
- Yi JingYi Jing
- Eric LondinEric Londin
- Phillipe LoherPhillipe Loher
- Huang-Wen ChenHuang-Wen Chen
- Paolo FortinaPaolo Fortina
Top Cited Papers
Open Access
- 1 January 2013
- journal article
- research article
- Published by Springer Nature in BMC Genomics
- Vol. 14 (1) , 1
Abstract
Human blood platelets are essential to maintaining normal hemostasis, and platelet dysfunction often causes bleeding or thrombosis. Estimates of genome-wide platelet RNA expression using microarrays have provided insights to the platelet transcriptome but were limited by the number of known transcripts. The goal of this effort was to deep-sequence RNA from leukocyte-depleted platelets to capture the complex profile of all expressed transcripts.Keywords
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