Site‐Selective O‐Arylation of Glycosides
Open Access
- 10 November 2017
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 57 (1) , 314-318
Abstract
Direct and site‐selective O‐arylation of carbohydrates has been a challenge in synthesis. Herein we report a method based on copper‐catalyzed O‐arylation to address this challenge. Proper choice of the ancillary ligand on copper is critical for the efficiency and site selectivity of this transformation. This method features mild conditions, tolerates various functional groups, and demonstrates broad substrate scope.Keywords
Funding Information
- National Natural Science Foundation of China (21602145, 21772125)
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