The Tetrazole 3-N-Oxide Synthesis
Authors:
- 26 March 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 75 (9) , 3141-3143
Abstract
An efficient procedure for transferring an oxygen atom to the 1- or 2-substituted 5-alkyl or aryl tetrazole ring, resulting, for the first time, in the corresponding N-oxides, was developed using HOF·CH3CN. This novel route features mild conditions and high yields. X-ray structure analysis and 15N NMR experiments indicate that the preferred position for the incorporation of the oxygen is on the N-3 atom.Keywords
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