Enantioselective γ-Alkylation of α,β-Unsaturated Malonates and Ketoesters by a Sequential Ir-Catalyzed Asymmetric Allylic Alkylation/Cope Rearrangement
- 7 April 2016
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 138 (16) , 5234-5237
Abstract
A catalytic, enantioselective γ-alkylation of α,β-unsaturated malonates and ketoesters is reported. This strategy entails a highly regio- and enantioselective iridium-catalyzed α-alkylation of an extended enolate, and a subsequent translocation of chirality to the γ-position via a Cope rearrangement.Keywords
Funding Information
- Gordon and Betty Moore Foundation
- California HIV/AIDS Research Program (F08-CT-201)
- National Institute of General Medical Sciences (R01GM080269)
- National Science Foundation
- California Institute of Technology
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