Antigenic cross‐reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis
Authors:
- 1 May 1988
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 10 (3) , 279-291
Abstract
Summary Cross‐reactivity was demonstrated between circulating antibodies from Trichuris trichiura‐infected humans and T. muris‐infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S‐methionine‐labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval β‐stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in ELISA, as did scrum from mice with patent T. muris worm burdens. This cross‐reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.Keywords
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