EFFICIENT CHEMO-ENZYMATIC SYNTHESES OF PHARMACEUTICALLY USEFUL UNNATURAL 2′-DEOXYNUCLEOSIDES
Authors:
- 1 April 2005
- journal article
- Published by Taylor & Francis in Nucleosides, Nucleotides & Nucleic Acids
- Vol. 24 (5-7) , 1127-1130
Abstract
Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2′-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-α-D-ribose 1...Keywords
This publication has 8 references indexed in Scilit:
- Chemo-enzymatic syntheses of natural and unnatural 2'-deoxynucleosidesNucleic Acids Symposium Series, 2003
- Chemo-enzymatic synthesis of 2′,3′-dideoxy-3′-fluoro-β-d-guanosine via 2,3-dideoxy-3-fluoro-α-d-ribose 1-phosphateTetrahedron Letters, 2003
- Efficient Syntheses of 2-Chloro-2‘-deoxyadenosine (Cladribine) from 2‘-Deoxyguanosine1The Journal of Organic Chemistry, 2003
- First Stereoselective Synthesis of 2-Deoxy-α-d-ribosyl-1-phosphate: Novel Application of Crystallization-Induced Asymmetric TransformationThe Journal of Organic Chemistry, 2002
- LARGE-SCALE MANUFACTURING OF ALL FOUR 2′-DEOXYNUCLEOSIDES VIA NOVEL STRATEGIES INCLUDING A CHEMO-ENZYMATIC PROCESSNucleosides, Nucleotides & Nucleic Acids, 2001
- Purine nucleoside synthesis: an efficient method employing nucleoside phosphorylasesBiochemistry, 1981
- Purine Nucleoside Phosphorylase from Escherichia coli and Salmonella typhimuriumEuropean Journal of Biochemistry, 1975
- Notes - 2-Chloroadenine and 2-ChloroadenosineThe Journal of Organic Chemistry, 1958