Palladium-Catalyzed Regioselective Carbonylation of 2-Trifluoromethyl-1,3-enynes to Multisubstituted Conjugated Dienes
- 19 January 2023
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 25 (4) , 682-687
Abstract
In this communication, a palladium-catalyzed regio- and stereoselective carbonylation of 2-trifluoromethyl-1,3-enynes to afford multisubstituted conjugated dienes has been realized. This protocol features excellent regio- and exclusive (E)-stereoselectivity and a broad substrate scope with both amines and alcohols as the suitable reaction partners and has shown promising functional group tolerance.Keywords
Funding Information
- K. C. Wong Education Foundation (GJTD-2020-08)
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