Chang-Sheng Kuai

A visible-light-induced photocatalytic carbonylative atom transfer radical addition reaction of alkenes has been developed. Various thioesters were produced in good yields.

This review summarizes key advances from 2018 to 2025 that demonstrate how selectivity in carbonylation can be effectively controlled not by the inherent reactivity of the substrate, but by the catalytic system itself.

A novel visible light-induced metal-free carbonylation method for the synthesis of β-trifluoromethylated thioesters has been developed.

An efficient strategy for the synthesis of acrylamides via palladium-catalyzed carbonylation, using 1,2-dichloroethane and amines as starting materials has been developed.

In this article, we disclose a method for the regiodivergent and stereoselective hydrosilylation of isoprene using an Earth-abundant cobalt catalyst via variation of ligands. With a less sterically hindered bidentate ligand, the reactions proceeded through 4,1-hydrosilylation to afford allylsilanes in excellent regio- and stereoselectivities. By switching to a bulkier ligand, the reactions were efficiently diverted to 2,1-addition products for the first time. This regiodivergent protocol provides a modular approach for the construction of structurally diverse organosilanes with high atom economy and without the formation of stoichiometric byproducts.

In this communication, a palladium-catalyzed regio- and stereoselective carbonylation of 2-trifluoromethyl-1,3-enynes to afford multisubstituted conjugated dienes has been realized. This protocol features excellent regio- and exclusive (E)-stereoselectivity and a broad substrate scope with both amines and alcohols as the suitable reaction partners and has shown promising functional group tolerance.

A metal-free difunctional carbonylation procedure toward the synthesis of olefin sulfonyl methyl esters has been developed. By employing easily available terminal alkynes and sodium sulfinates as the starting materials, a broad range of olefin sulfonyl methyl esters were synthesized in moderate to good yields via radical intermediates.

An atom-economical, regio- and enantioselective allylic alkylation of pyrazol-5-ones with alkynes was developed under rhodium catalysis.