Determination of Amine-Containing Drugs in Micellar Matrices by Spectrophotometry Using Box–Behnken Plans

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Abstract
The results of using the “response surface” methodology and the Box–Behnken design in the spectrophotometric determination of medicinal substances in a micellar matrix are presented on examples of dapsone and procaine. 5,7-Dichloro-4,6-dinitrobenzofuroxan is used as a reagent. The design of the neonol–water (80%)–dimethyl sulfoxide (20%) composition matrix is varied using the following factors: reagent concentration, pH, and neonol concentration. Optimization is performed using a three-level Box–Behnken plan. A significant increase in the intensity of the absorption band of the reaction products in the micellar pseudophase is shown. The optimal conditions under which medicinal substances can be determined by spectrophotometry in liquid and solid medicinal forms are found.

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