Atenolol versus pindolol: Side-effects in hypertension
Authors:
- 1 January 1985
- journal article
- clinical trial
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 28 (S1) , 89-91
Abstract
This randomized crossover out-patient study was designed to compare the antihypertensive effects of atenolol and pindolol. After a wash-out period of two weeks in pretreated cases, 107 patients with essential hypertension were given either atenolol 100 mg once-daily or pindolol 20 mg slow release (SR) once-daily. Both atenolol and pindolol lowered blood pressure over the 24 week period. The diastolic blood pressure reduction was significantly greater (pppppβ-blockers was the higher incidence of sleep disturbances with pindolol which may be due to the higher lipophilicity of this β-blocker.Keywords
This publication has 9 references indexed in Scilit:
- A Comparative Study Between 100mg Atenolol and 20mg Pindolol Slow-Release in Essential HypertensionDrugs, 1983
- Atenolol in hypertension: follow-up of patients crossed over to this agent from propranolol, pindolol or metoprolol.1980
- The clinical importance of cardioselectivity and lipophilicity in beta blockersAmerican Heart Journal, 1980
- Clinical pharmacology of the new beta-adrenergic blocking drugs. Part 1. Pharmacodynamic and pharmacokinetic propertiesAmerican Heart Journal, 1979
- A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.British Journal of Clinical Pharmacology, 1979
- Atenolol and three nonselective β‐blockers in hypertensionClinical Pharmacology & Therapeutics, 1979
- A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.1979
- Randomised study of six beta-blockers and a thiazide diuretic in essential hypertensionBMJ, 1978
- Pindolol: a comparison with other antihypertensive drugs and a double-blind placebo trial.1974