Regioselective Ortho Amination of an Aromatic C–H Bond by Trifluoroacetic Acid via Electrochemistry
- 5 July 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 21 (14) , 5581-5585
Abstract
A trifluoroacetic acid-facilitated ortho amination of alkoxyl arene has been established via anodic oxidation in an undivided cell. In the absence of any additional metal or oxidant reagents, a series of aromatic and heteroaromatic amine derivatives have been synthesized in good to excellent yields. Our findings reveal the possibility of achieving complete ortho-selective amination of a simple arene, which emerges as an efficient route for facile and large-scale organic synthesis.Keywords
Funding Information
- Ministry of Science and Technology of the People's Republic of China (2017YFA0206903)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018031)
- National Natural Science Foundation of China (21861132004, 21603248)
- Chinese Academy of Sciences (XDB17000000, QYZDY-SSW-JSC029)
- K.C. Wong Education Foundation
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