Gadoxetate Disodium–Enhanced Hepatic MRI: Dose-Dependent Contrast Dynamics of Hepatic Parenchyma and Portal Vein

Authors:
Publisher website
Google Scholar
Abstract
OBJECTIVE. The purpose of this study was to investigate the relative enhancement characteristics of the hepatic parenchyma and portal vein during gadoxetate disodium–enhanced abdominal MRI and to assess whether contrast between the portal vein and the hepatic parenchyma can be improved with higher doses of gadoxetate disodium.MATERIALS AND METHODS. A total of 102 patients (61 women, 41 men) underwent gadoxetate disodium–enhanced abdominal MRI. They received a weight-independent dose of 10 mL of gadoxetate disodium, corresponding to a dose spectrum of 0.02–0.06 mmol/kg body weight. The patients were assigned to one of three dose groups: recommended dose (0.02–0.03 mmol/kg), intermediate dose (0.03–0.045 mmol/kg), or high dose (0.045–0.06 mmol/kg). The signal-to-noise ratios for the portal vein, liver, and the portal vein–to–liver contrast-to-noise ratio were calculated for three consecutive arterial phases, one portal venous phase, and four delayed imaging phases.RESULTS. The delayed phase images of the li...

This publication has 22 references indexed in Scilit: