Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and p , p ′-DDT
Authors:
- 9 April 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3979) , 167-169
Abstract
Aryl hydrocarbon hydroxylase induction by phenobarbital, polycyclic hydrocarbons, and the insecticide, 2.2-bis(p-chlorophenyl)-1,1,1-trichloroethane ( p , p ′-DDT), occurs in rat fetal liver cell cultures. The maximum net rate at which the hydroxylase activity accumulates is about the same when phenobarbital, 3-methylcholanthrene, or benz[ a ]anthracene is in the growth medium at optimum concentrations. An additive effect is obtained when either phenobarbital or p , p ′-DDT is present with a polycyclic hydrocarbon in the growth medium, but not when the cells are treated with phenobarbital plus p , p ′-DDT or with the combination of two polycyclic hydrocarbons.Keywords
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